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Immunodysfunction: A Cause of Stealth COVID-19 Illness and Death 

View OpEd:  

1. Sun LH, Achenbach J. The doctor won’t see you now: Covid winters are making long hospital waits the new normal. The Washington Post. Jan. 17 2023.
2. CDC Media Telebriefing: Update on Respiratory Disease Circulation Transcript. Fri. Nov. 4, 2022.
3. Disease Burden of Flu. Cneters for Disease Contorl and Prevention. Oct. 4, 2022.
4. RSV National Trends. CDC. html

5. Staff and agencies in Berlin. Germany faces ‘catastrophic’ paediatric bed shortage as RSV cases soar. The Guardian. Dec. 1, 2022.
6. Tanenbaum T, Doenhardt M, Diffloth N, et al. High burden of RSV hospitalizations in Germany 2021-2022. Infection. Dec. 2022.
7. Persson F. Rekordmånga sjuka barn – rummen med syrgas räcker inte på barnakuten. Goteborgs-Posten. Dec. 16, 2022.
8. Wang L, Davis PB, Berger NA, et al. Disruption in seasonality, patient characteristics and disparities of respiratory syncytial virus infection among young children in the US during and before the COVID-19 pandemic: 2010-2022. medRxiv. Nov. 29, 2022.
9. Dalton J. Sixth child dies of Strep A infection as scarlet fever cases surge. Independent. Dec. 2, 2022.
10. Increase in Invasive Group A Strep Infections, 2022–2023. Centers for Disease Control and Prevention. Dec. 22, 2022.
11. UKHSA update on scarlet fever and invasive group A strep. UK Health Security Agency. Jan. 12, 2023. 

12. Mizrahi B, Sudry T, Flaks-Manov N., et al. Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study. The BMJ. Jan. 11, 2023.
13. Sarden N, Sinha S, Potts KG, et al. A B1a–natural IgG–neutrophil axis is impaired in viral- and steroid-associated aspergillosis. Science Tanslational Medicine. Dec. 7, 2022.
14. Ting G. Chinese hospital staff report severe disease linked to reinfections with Omicron. Radio Free Asia. Jan. 13, 2023.
15. Katz J, Yue S, Xue W. Herpes simplex and herpes zoster viruses in COVID-19 patients. Ir J Med Sci. 2022 Jun;191(3):1093-1097. doi: 10.1007/s11845-021-02714-z. Epub 2021 Jul 11.
16. Waltz E. Could long COVID be linked to herpes viruses? Early data offer a hint. Nature. Aug. 25, 2022.
17. Nikiforuk A. What If COVID Reinfections Wear Down Our Immunity? The Tyee. Nov. 7, 2022.
18. Leonardi AJ, Proenca RB. Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19. Frontiers. Dec. 21, 2020.
19. Shen, XR., Geng, R., Li, Q. et al. ACE2-independent infection of T lymphocytes by SARS-CoV-2. Sig Transduct Target Ther 7, 83 (2022).
20. Phetsouphanh, C., Darley, D.R., Wilson, D.B. et al. Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nat Immunol 23, 210–216 (2022).
21. Chattopadhyay P, Khare K, Kumar M, et al. Front. Immunol., 02 December 2022
Sec. Viral Immunology. Volume 13 - 2022 |
22. Files JK, Boppana S, Perez MD, Sarkar S, Lowman KE, Qin K, Sterrett S, Carlin E, Bansal A, Sabbaj S, Long DM, Kutsch O, Kobie J, Goepfert PA, Erdmann N. Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. J Clin Invest. 2021 Jan 4;131(1):e140491. doi: 10.1172/JCI140491. PMID: 33119547; PMCID: PMC7773371.
23. Song CY, Xu J, He JQ, Lu YQ. Immune dysfunction following COVID-19, especially in severe patients. Sci Rep. 2020 Sep 28;10(1):15838. doi: 10.1038/s41598-020-72718-9. PMID: 32985562; PMCID: PMC7522270.
24. Al-Aly, Z., Xie, Y. & Bowe, B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature 594, 259–264 (2021).  

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